The total synthesis of K-252c (staurosporinone) via a sequential C-H functionalisation strategy.
نویسندگان
چکیده
A synthesis of the bioactive indolocarbazole alkaloid K-252c (staurosporinone) via a sequential C-H functionalisation strategy is reported. The route exploits direct functionalisation reactions around a simple arene core and comprises of two highly-selective copper-catalysed C-H arylations, a copper-catalysed C-H amination and a palladium-catalysed C-H carbonylation, which build up the structural complexity of the natural product framework.
منابع مشابه
The total synthesis of K-252c (staurosporinone) via a sequential C–H functionalisation strategy† †Electronic supplementary information (ESI) available: 1H and 13C NMR spectra, and crystallographic data. CCDC 1431476. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc04399a Click here for additional data file. Click here for additional data file.
A synthesis of the bioactive indolocarbazole alkaloid K-252c (staurosporinone) via a sequential C–H functionalisation strategy is reported. The route exploits direct functionalisation reactions around a simple arene core and comprises of two highly-selective copper-catalysed C–H arylations, a coppercatalysed C–H amination and a palladium-catalysed C–H carbonylation, which build up the structura...
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ورودعنوان ژورنال:
- Chemical science
دوره 7 4 شماره
صفحات -
تاریخ انتشار 2016